I. How Common is Hearing Loss?

  • Hearing loss and deafness are surprisingly common, affecting up to 5% of the world’s population.

II. Causes of Hearing Loss

  • Congenital Deafness:
    • Caused by mutations in genes responsible for the intricate structure of the inner ear.
    • Examples: molecules for cochlear fluid, hair cell function etc.
    • Any mutation affecting these can lead to deafness or severe hearing impairment.
  • Medications:
    • Certain chemotherapeutic drugs and antibiotics can be toxic to hair cells, causing hearing loss.

III. Presbyacusis (Age-Related Hearing Loss)

  • Most common cause of hearing loss in adults.
  • Caused by:
    • Loss of outer hair cells in the cochlea.
    • Inner hair cells (responsible for transmitting information to the brain) remain relatively intact.
    • This loss disrupts the cochlear amplifier, leading to significant hearing difficulties.
  • Contributing factors:
    • Exposure to loud noises over time.

IV. Impact of Presbyacusis

  • Hearing loss at high frequencies first.

  • Speech becomes difficult to understand, especially sounds like “f,” “s,” and “th.”

  • Difficulty following conversations, particularly in noisy environments. V. Demonstration of Presbyacusis on Audiogram

  • Normal hearing threshold: 0 decibels across most frequencies.

  • Presbyacusis: Relatively normal hearing at low frequencies, but significantly elevated thresholds (requiring much louder sounds) at high frequencies.

  • High-frequency sounds crucial for understanding speech are most affected.

VI. Progression of Presbyacusis

  • Over time, hearing loss can progress to lower and lower frequencies.
  • This can lead to severe hearing impairment in older adults.